Embryonal precursors of Wilms tumor

MiR-21 Expression in Wilms’ Tumor

Background and Objective: Wilms’ tumor (WT) is the most common genitourinary tract tumor in children. MicroRNAs (miRNAs) are small non-coding RNAs; their role in the pathogenesis of many types of human cancers has been identified. We aimed to evaluate the expression of miR-21, a well-known oncomir, in WT tissue samples which is a very common urinary tract malignancy in children...

Wilms Tumor

[Wilms' tumor].

Today the prognosis in children with nephroblastoma is excellent. With the combination of surgery, chemotherapy and radiation more than 80% of children can be cured. Because of acute toxicity and late effects of treatment (scoliosis, cardiotoxicity, fertility problems and second malignancies) a major issue in the management of children with this kind of malignancy is the reduction of chemothera...

Phylogeny of Wilms tumor?

Article history: Received 28 June 2016 Accepted 28 June 2016 Available online 4 July 2016 pathway) and genetic progression (e.g., the Fearon-Vogelstein pathway Fearon and Vogelstein, 1990). Steps in adult tumor pathogenesis was suggested by Armitage and Doll 60 years ago (Armitage and Doll, 1954), with around 7 steps. The question then for pediatric tumors, is how do steps occur at such a young...

Kidney : Nephroblastoma ( Wilms tumor )

Other names: Nephroblastoma Note: Wilms' tumor, although generally rare, is the most common abdominal malignancy in children. Wilms' tumor cells are believed to derive from pluripotent embyronic renal precursor cells. Thus, Wilms' tumors are linked to the early development of the kidney. While most are isolated sporadic tumors, approximately 10% of cases are associated with genetic syndromes an...